Version 5.4
Mus musculus Protein: Six3
Summary
InnateDB Protein IDBP-713096.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Six3
Protein Name
Synonyms E130112M24Rik; Six3a; Six3alpha; Six3b; Six3beta;
Species Mus musculus
Ensembl Protein ENSMUSP00000135677
InnateDB Gene IDBG-201024 (Six3)
Protein Structure
UniProt Annotation
Function Transcriptional repressor essential for eye and forebrain development. Involved in the development of the forebrain by negatively regulating the expression of WNT1. Plays an important role during retina development and lens morphogenesis in an AES and TLE4-dependent manner. {ECO:0000269PubMed:12050133, ECO:0000269PubMed:12569128, ECO:0000269PubMed:20682799}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12050133}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001654 eye development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0007420 brain development
GO:0021536 diencephalon development
GO:0021537 telencephalon development
GO:0021797 forebrain anterior/posterior pattern specification
GO:0030178 negative regulation of Wnt signaling pathway
GO:0043010 camera-type eye development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048512 circadian behavior
GO:0060235 lens induction in camera-type eye
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:102764
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
PFAM PF00046
PRINTS
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62233
PhosphoSite PhosphoSite-Q62233
TrEMBL
UniProt Splice Variant
Entrez Gene 20473
UniGene Mm.437682
RefSeq
MGI ID
MGI Symbol Six3
OMIM
CCDS CCDS50203
HPRD
IMGT
EMBL BC098096 D83144 D83145 X90871
GenPept AAH98096 BAA11822 BAA11823 CAA62379

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca