Version 5.4
Homo sapiens Protein: SENP5
Summary
InnateDB Protein IDBP-71374.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP5
Protein Name SUMO1/sentrin specific peptidase 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000327197
InnateDB Gene IDBG-71372 (SENP5)
Protein Structure
UniProt Annotation
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. {ECO:0000269PubMed:16608850, ECO:0000269PubMed:16738315}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:16608850, ECO:0000269PubMed:16738315}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007049 cell cycle
GO:0016925 protein sumoylation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1
PFAM PF02902
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96HI0
PhosphoSite PhosphoSite-Q96HI0
TrEMBL C9JHT8
UniProt Splice Variant
Entrez Gene 205564
UniGene Hs.601136
RefSeq NP_689912
HUGO HGNC:28407
OMIM 612845
CCDS CCDS3322
HPRD 10222
IMGT
EMBL AC011322 AC016949 AC127904 AF335474 BC008589 BC030705 CH471191
GenPept AAH08589 AAH30705 AAK69630 EAW53625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca