InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNL3L

Summary

InnateDB Protein

IDBP-71379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNL3L

Protein Name

guanine nucleotide binding protein-like 3 (nucleolar)-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354091

InnateDB Gene

IDBG-71375 (GNL3L)

Protein Structure

UniProt Annotation

Function

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269PubMed:16251348, ECO:0000269PubMed:17034816, ECO:0000269PubMed:19487455, ECO:0000269PubMed:21132010}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:17034816}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0044822	poly(A) RNA binding