InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PINX1

Summary

InnateDB Protein

IDBP-7142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PINX1

Protein Name

PIN2/TERF1 interacting, telomerase inhibitor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318966

InnateDB Gene

IDBG-404872 (PINX1)

Protein Structure

UniProt Annotation

Function

Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. {ECO:0000269PubMed:15381700, ECO:0000269PubMed:17198684, ECO:0000269PubMed:19117989, ECO:0000269PubMed:19265708, ECO:0000269PubMed:19393617, ECO:0000269PubMed:19553660}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

Disease Associations

Tissue Specificity

Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0010521	telomerase inhibitor activity
GO:0070034	telomeric RNA binding

Biological Process

GO:0007004	telomere maintenance via telomerase
GO:0007080	mitotic metaphase plate congression
GO:0008285	negative regulation of cell proliferation
GO:0045786	negative regulation of cell cycle
GO:0051972	regulation of telomerase activity
GO:0051974	negative regulation of telomerase activity

Cellular Component

GO:0000228	nuclear chromosome
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000781	chromosome, telomeric region
GO:0005575	cellular_component
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0005819	spindle