InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syngap1

Summary

InnateDB Protein

IDBP-714372.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syngap1

Protein Name

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137587

InnateDB Gene

IDBG-156093 (Syngap1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007265	Ras protein signal transduction
GO:0007389	pattern specification process
GO:0008542	visual learning
GO:0016358	dendrite development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0043113	receptor clustering
GO:0043408	regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0050771	negative regulation of axonogenesis
GO:0050803	regulation of synapse structure and activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0043198	dendritic shaft

Protein Structure and Domains

PDB ID

MGI:3039785

InterPro

IPR000008 C2 domain
IPR001849 Pleckstrin homology domain
IPR001936 Ras GTPase-activating protein
IPR008936 Rho GTPase activation protein
IPR021887 Protein of unknown function DUF3498

PFAM

PF00168
PF00169
PF00616
PF12004

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00233
SM00323

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt