InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MFI2

Summary

InnateDB Protein

IDBP-71454.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MFI2

Protein Name

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

Synonyms

CD228; MAP97; MTF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000296351

InnateDB Gene

IDBG-71450 (MFI2)

Protein Structure

UniProt Annotation

Function

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc. {ECO:0000269PubMed:7556058}.

Subcellular Localization

Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.

Disease Associations

Tissue Specificity

Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008199	ferric iron binding

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0010756	positive regulation of plasminogen activation
GO:0090091	positive regulation of extracellular matrix disassembly
GO:0097286	iron ion import
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome