InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccr6

Summary

InnateDB Protein

IDBP-714617.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr6

Protein Name

Synonyms

CC-CKR-6; CCR-6; Cmkbr6; KY411;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137249

InnateDB Gene

IDBG-135484 (Ccr6)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1333797

InterPro

IPR000190 Angiotensin II receptor type 1
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR004067 CC chemokine receptor 6
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00635
PR00237
PR00657
PR01529

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O54689