Version 5.4
Mus musculus Protein: Arhgdig
Summary
InnateDB Protein IDBP-714850.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgdig
Protein Name
Synonyms Gdi5; Rho-GDI-3; Rho-GDI2; RIP2;
Species Mus musculus
Ensembl Protein ENSMUSP00000135717
InnateDB Gene IDBG-154871 (Arhgdig)
Protein Structure
UniProt Annotation
Function Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity Detected only in brain, lung, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0032880 regulation of protein localization
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:108430
InterPro IPR000406 RHO protein GDP dissociation inhibitor
IPR014756 Immunoglobulin E-set
PFAM PF02115
PRINTS PR00492
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62160
PhosphoSite PhosphoSite-Q62160
TrEMBL Q3UNB6
UniProt Splice Variant
Entrez Gene 14570
UniGene
RefSeq
MGI ID
MGI Symbol Arhgdig
OMIM
CCDS CCDS28548
HPRD
IMGT
EMBL AK144321 BC002032 BC158003 CH466606 L42463 U73198
GenPept AAB18196 AAC37704 AAH02032 AAI58004 BAE25831 EDL22493

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca