InnateDB Protein
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IDBP-715110.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wnk1
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Protein Name
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000136086
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InnateDB Gene
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IDBG-183036 (Wnk1)
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Protein Structure
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Function |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. {ECO:0000269PubMed:12671053}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11498583}.
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Disease Associations |
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Tissue Specificity |
Widely expressed in both adult and embryonic tissue, with highest levels observed in the testis and lower levels in heart, lung, kidney, placenta, brain and skeletal muscle. Two isoforms are expressed in heart, a single shorter isoform in the kidney. Locates to the distal convoluted tubule, the medullary collecting duct and the cortical collecting duct of the kidney. HSN2-containing isoform 2 and isoform 3 are restricted to the nervous system, expressed preferentially in sensory neurons than in motor neurons and in general more abundant in axons than in cell bodies (at protein level). In the DRG, predominantly expressed in the satellite cells that envelop sensory neurons, but low expression also observed in the cell bodies of neurons (at protein level). In the sciatic nerve, expressed in the Schwann cells that surround axons and in a mosaic distribution of axons (at protein level). In the spinal cord, expressed in superficial layers (LI and LII), as well as in the fibers of the Lissauer tract (at protein level). Also detected in the axon fibers of dorsolateral funiculus and lateral funiculus (at protein level). {ECO:0000269PubMed:11498583, ECO:0000269PubMed:14514722, ECO:0000269PubMed:18521183}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
67 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2442092
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P83741
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PhosphoSite |
PhosphoSite-P83741
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
232341
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UniGene |
Mm.410746
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RefSeq |
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MGI ID |
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MGI Symbol |
Wnk1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC113092
AC117667
AK133738
AK172935
AY309076
BC056761
BC138445
BC145282
BC146009
BC146011
BC171955
BK004107
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GenPept |
AAH56761
AAI38446
AAI45283
AAI46010
AAI46012
AAI71955
AAQ77243
BAD32213
BAE21813
DAA04493
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