Version 5.4
Mus musculus Gene: Wnk1
Summary
InnateDB Gene IDBG-183036.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wnk1
Gene Name WNK lysine deficient protein kinase 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000045962
Encoded Proteins
IDBP-183038
WNK lysine deficient protein kinase 1
IDBP-183040
WNK lysine deficient protein kinase 1
IDBP-183042
WNK lysine deficient protein kinase 1
IDBP-715110
IDBP-535250
WNK lysine deficient protein kinase 1
IDBP-540668
WNK lysine deficient protein kinase 1
IDBP-535950
WNK lysine deficient protein kinase 1
IDBP-533425
WNK lysine deficient protein kinase 1
IDBP-532009
WNK lysine deficient protein kinase 1
IDBP-540555
WNK lysine deficient protein kinase 1
IDBP-537075
WNK lysine deficient protein kinase 1
IDBP-536352
WNK lysine deficient protein kinase 1
IDBP-536650
WNK lysine deficient protein kinase 1
IDBP-715589
IDBP-715871
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000060237:
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:119923969-120038672
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000088644 ENSMUSP00000086017
ENSMUST00000060043 ENSMUSP00000063001
ENSMUST00000088646 ENSMUSP00000086019
ENSMUST00000035513
ENSMUST00000161512 ENSMUSP00000136086
ENSMUST00000159903
ENSMUST00000160493 ENSMUSP00000124377
ENSMUST00000161243 ENSMUSP00000124050
ENSMUST00000162190 ENSMUSP00000125686
ENSMUST00000160872 ENSMUSP00000123739
ENSMUST00000162541 ENSMUSP00000125193
ENSMUST00000161802 ENSMUSP00000124724
ENSMUST00000160820
ENSMUST00000161185
ENSMUST00000162368 ENSMUSP00000125383
ENSMUST00000159785 ENSMUSP00000124905
ENSMUST00000161048 ENSMUSP00000125345
ENSMUST00000160769
ENSMUST00000159397
ENSMUST00000160686 ENSMUSP00000137334
ENSMUST00000161392
ENSMUST00000159151
ENSMUST00000177761 ENSMUSP00000136777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019869 chloride channel inhibitor activity
GO:0019902 phosphatase binding
Biological Process
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006811 ion transport
GO:0010923 negative regulation of phosphatase activity
GO:0035556 intracellular signal transduction
GO:0050794 regulation of cellular process
GO:0090188 negative regulation of pancreatic juice secretion
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000060237
View Gene Order
ENSBTAG00000005221
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P83741
TrEMBL
UniProt Splice Variant
Entrez Gene 232341
UniGene Mm.333349 Mm.407008 Mm.410746
RefSeq NM_001185021 NM_001185020 NM_001199083 NM_001199084 NM_198703
OMIM
CCDS CCDS51888 CCDS20478 CCDS57444 CCDS57445
HPRD
IMGT
MGI ID MGI:2442092
MGI Symbol Wnk1
EMBL AC113092 AC117667 AK133738 AK172935 AY309076 BC056761 BC138445 BC145282 BC146009 BC146011 BC171955 BK004107
GenPept AAH56761 AAI38446 AAI45283 AAI46010 AAI46012 AAI71955 AAQ77243 BAD32213 BAE21813 DAA04493
RNA Seq Atlas 232341

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca