InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt5b

Summary

InnateDB Protein

IDBP-715519.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt5b

Protein Name

Synonyms

AW545702; Wnt-5b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137065

InnateDB Gene

IDBG-182694 (Wnt5b)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0009887	organ morphogenesis
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030335	positive regulation of cell migration
GO:0042060	wound healing
GO:0045165	cell fate commitment
GO:0045600	positive regulation of fat cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0009986	cell surface
GO:0031012	extracellular matrix