InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Disp1

Summary

InnateDB Protein

IDBP-716348.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Disp1

Protein Name

Synonyms

1190008H24Rik; DispA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126742

InnateDB Gene

IDBG-704884 (Disp1)

Protein Structure

UniProt Annotation

Function

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. {ECO:0000269PubMed:12372258, ECO:0000269PubMed:12372301, ECO:0000269PubMed:12421714}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008158	hedgehog receptor activity
GO:0015197	peptide transporter activity

Biological Process

GO:0007224	smoothened signaling pathway
GO:0007225	patched ligand maturation
GO:0007368	determination of left/right symmetry
GO:0007389	pattern specification process
GO:0009880	embryonic pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0015833	peptide transport
GO:0060539	diaphragm development