Version 5.4
Mus musculus Gene: Disp1
Summary
InnateDB Gene IDBG-704884.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Disp1
Gene Name dispatched homolog 1 (Drosophila)
Synonyms 1190008H24Rik; DispA
Species Mus musculus
Ensembl Gene ENSMUSG00000030768
Encoded Proteins
IDBP-714407
IDBP-716348
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154309:
The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:183086264-183221529
Strand Reverse strand
Band H5
Transcripts
ENSMUST00000003035 ENSMUSP00000003035
ENSMUST00000171366 ENSMUSP00000126742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008158 hedgehog receptor activity
GO:0015197 peptide transporter activity
Biological Process
GO:0007224 smoothened signaling pathway
GO:0007225 patched ligand maturation
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0009880 embryonic pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0015833 peptide transport
GO:0060539 diaphragm development
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000154309
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
Cross-References
SwissProt Q3TDN0
TrEMBL
UniProt Splice Variant
Entrez Gene 68897
UniGene Mm.358721
RefSeq NM_001278220 NM_001278218 NM_001278219 NM_026866 XM_006535596
OMIM
CCDS CCDS56661
HPRD
IMGT
MGI ID MGI:1916147
MGI Symbol Disp1
EMBL AK004521 AK138276 AK170113 AY144589 AY150577 AY150698 BC043102 BC059225
GenPept AAH43102 AAH59225 AAN08631 AAN52161 AAN64660 BAB23344 BAE23607 BAE41571
RNA Seq Atlas 68897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca