InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rabep1

Summary

InnateDB Protein

IDBP-716646.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rabep1

Protein Name

Synonyms

Rab5ep; rabaptin-5; rabaptin-5alpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000137267

InnateDB Gene

IDBG-195535 (Rabep1)

Protein Structure

UniProt Annotation

Function

Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity