InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gclm

Summary

InnateDB Protein

IDBP-717122.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gclm

Protein Name

Synonyms

AI649393; Gcmc; Glclr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136987

InnateDB Gene

IDBG-191550 (Gclm)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004357	glutamate-cysteine ligase activity
GO:0035226	glutamate-cysteine ligase catalytic subunit binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006534	cysteine metabolic process
GO:0006536	glutamate metabolic process
GO:0006749	glutathione metabolic process
GO:0006750	glutathione biosynthetic process
GO:0006979	response to oxidative stress
GO:0008637	apoptotic mitochondrial changes
GO:0035229	positive regulation of glutamate-cysteine ligase activity
GO:0042493	response to drug
GO:0043524	negative regulation of neuron apoptotic process
GO:0050880	regulation of blood vessel size
GO:0051409	response to nitrosative stress
GO:0051900	regulation of mitochondrial depolarization
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway