InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCB9

Summary

InnateDB Protein

IDBP-717515.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB9

Protein Name

Synonyms

EST122234; TAPL;

Species

Homo sapiens

Ensembl Protein

ENSP00000456813

InnateDB Gene

IDBG-63048 (ABCB9)

Protein Structure

UniProt Annotation

Function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. {ECO:0000269PubMed:15863492, ECO:0000269PubMed:17977821, ECO:0000269PubMed:18434309}.

Subcellular Localization

Lysosome membrane {ECO:0000269PubMed:10748049, ECO:0000269PubMed:15577206, ECO:0000269PubMed:17897319, ECO:0000269PubMed:17977821, ECO:0000269PubMed:18175933, ECO:0000269PubMed:18952056, ECO:0000269PubMed:20377823, ECO:0000269PubMed:21212514}; Multi- pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441, ECO:0000269PubMed:10748049, ECO:0000269PubMed:15577206, ECO:0000269PubMed:17897319, ECO:0000269PubMed:17977821, ECO:0000269PubMed:18175933, ECO:0000269PubMed:18952056, ECO:0000269PubMed:20377823, ECO:0000269PubMed:21212514}. Note=May be located in membrane rafts.

Disease Associations

Tissue Specificity

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages. {ECO:0000269PubMed:10748049, ECO:0000269PubMed:17977821}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015440	peptide-transporting ATPase activity
GO:0016887	ATPase activity
GO:0022891	substrate-specific transmembrane transporter activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0042803	protein homodimerization activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015031	protein transport
GO:0015833	peptide transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NP78

PhosphoSite