InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACVR2A

Summary

InnateDB Protein

IDBP-71763.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACVR2A

Protein Name

activin A receptor, type IIA

Synonyms

ACTRII; ACVR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000241416

InnateDB Gene

IDBG-71761 (ACVR2A)

Protein Structure

UniProt Annotation

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015026	coreceptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017002	activin-activated receptor activity
GO:0019838	growth factor binding
GO:0030165	PDZ domain binding
GO:0034711	inhibin binding
GO:0043621	protein self-association
GO:0046872	metal ion binding
GO:0048185	activin binding

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007283	spermatogenesis
GO:0007368	determination of left/right symmetry
GO:0007498	mesoderm development
GO:0008584	male gonad development
GO:0009952	anterior/posterior pattern specification
GO:0009966	regulation of signal transduction
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030510	regulation of BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0042713	sperm ejaculation
GO:0043084	penile erection
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0048706	embryonic skeletal system development
GO:0050999	regulation of nitric-oxide synthase activity
GO:0060011	Sertoli cell proliferation
GO:0071773	cellular response to BMP stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0034673	inhibin-betaglycan-ActRII complex

Protein Structure and Domains

PDB ID

InterPro

IPR000333 Ser/Thr protein kinase, TGFB receptor
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714

PRINTS

PR00653
PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt