InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfr1

Summary

InnateDB Protein

IDBP-717663.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfr1

Protein Name

Synonyms

AW208770; bFGF-R-1; c-fgr; Eask; Fgfr-1; FLG; Flt-2; Hspy; MFR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136640

InnateDB Gene

IDBG-143767 (Fgfr1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001525	angiogenesis
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001759	organ induction
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0006468	protein phosphorylation
GO:0007420	brain development
GO:0007435	salivary gland morphogenesis
GO:0007605	sensory perception of sound
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0048339	paraxial mesoderm development
GO:0048378	regulation of lateral mesodermal cell fate specification
GO:0048469	cell maturation
GO:0048514	blood vessel morphogenesis
GO:0048699	generation of neurons
GO:0048762	mesenchymal cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060117	auditory receptor cell development
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:95522

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000628

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References