InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZW10

Summary

InnateDB Protein

IDBP-71809.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZW10

Protein Name

ZW10, kinetochore associated, homolog (Drosophila)

Synonyms

HZW10; KNTC1AP;

Species

Homo sapiens

Ensembl Protein

ENSP00000200135

InnateDB Gene

IDBG-71807 (ZW10)

Protein Structure

UniProt Annotation

Function

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. {ECO:0000269PubMed:11590237, ECO:0000269PubMed:15029241, ECO:0000269PubMed:15094189, ECO:0000269PubMed:15485811, ECO:0000269PubMed:15824131}.

Subcellular Localization

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019237	centromeric DNA binding

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000132	establishment of mitotic spindle orientation
GO:0000278	mitotic cell cycle
GO:0006461	protein complex assembly
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0007067	mitotic nuclear division
GO:0007080	mitotic metaphase plate congression
GO:0007093	mitotic cell cycle checkpoint
GO:0007096	regulation of exit from mitosis
GO:0007126	meiotic nuclear division
GO:0015031	protein transport
GO:0034501	protein localization to kinetochore

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0016020	membrane