Version 5.4
Homo sapiens Gene: ZW10
Summary
InnateDB Gene IDBG-71807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZW10
Gene Name ZW10, kinetochore associated, homolog (Drosophila)
Synonyms HZW10; KNTC1AP
Species Homo sapiens
Ensembl Gene ENSG00000086827
Encoded Proteins
IDBP-71809
ZW10, kinetochore associated, homolog (Drosophila)
IDBP-591563
ZW10, kinetochore associated, homolog (Drosophila)
IDBP-593172
ZW10, kinetochore associated, homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:113733187-113773811
Strand Reverse strand
Band q23.2
Transcripts
ENST00000200135 ENSP00000200135
ENST00000535142 ENSP00000440879
ENST00000538209 ENSP00000439197
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019237 centromeric DNA binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000132 establishment of mitotic spindle orientation
GO:0000278 mitotic cell cycle
GO:0006461 protein complex assembly
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0007093 mitotic cell cycle checkpoint
GO:0007096 regulation of exit from mitosis
GO:0007126 meiotic nuclear division
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005828 kinetochore microtubule
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032264
View Gene Order
ENSBTAG00000020066
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O43264
TrEMBL A1A528 B4E1J7
UniProt Splice Variant
Entrez Gene 9183
UniGene Hs.503886 Hs.644799
RefSeq NM_004724
HUGO HGNC:13194
OMIM 603954
CCDS CCDS8363
HPRD 04902
IMGT
EMBL AK303871 AP002436 AP003170 BC128264 U54996
GenPept AAB88237 AAI28265 BAG64809
RNA Seq Atlas 9183

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca