InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Purb

Summary

InnateDB Protein

IDBP-718353.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Purb

Protein Name

Synonyms

2310015K15Rik; AA114818; Cager-2; D11Bwg0414e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136957

InnateDB Gene

IDBG-709967 (Purb)

Protein Structure

UniProt Annotation

Function

Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. {ECO:0000250, ECO:0000269PubMed:11751932, ECO:0000269PubMed:9334258}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0006268	DNA unwinding involved in DNA replication
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008283	cell proliferation
GO:0030154	cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated