Version 5.4
Mus musculus Gene: Purb
Summary
InnateDB Gene IDBG-709967.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Purb
Gene Name purine rich element binding protein B
Synonyms 2310015K15Rik; AA114818; Cager-2; D11Bwg0414e
Species Mus musculus
Ensembl Gene ENSMUSG00000094483
Encoded Proteins
IDBP-718353
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146676:
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:6467599-6475917
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000179343 ENSMUSP00000136957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003691 double-stranded telomeric DNA binding
GO:0003697 single-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
GO:0046332 SMAD binding
Biological Process
GO:0006268 DNA unwinding involved in DNA replication
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146676
View Gene Order
ENSBTAG00000046625
Not yet available
Cross-References
SwissProt O35295
TrEMBL Q3UTJ8 Q8BQK8
UniProt Splice Variant
Entrez Gene 19291
UniGene Mm.296150 Mm.390332 Mm.405163 Mm.409293 Mm.466928 Mm.471532 Mm.474493 Mm.474938 Mm.486423 Mm.486502 Mm.486513 Mm.488008
RefSeq NM_011221
OMIM
CCDS CCDS24420
HPRD
IMGT
MGI ID MGI:1338779
MGI Symbol Purb
EMBL AF017630 AK049443 AK139376 AL646020
GenPept AAB71859 BAC33753 BAE23982 CAI26011
RNA Seq Atlas 19291

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca