InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ebf2

Summary

InnateDB Protein

IDBP-718648.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ebf2

Protein Name

Synonyms

D14Ggc1e; EBF-2; Mmot1; O/E-3; OE-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135782

InnateDB Gene

IDBG-175890 (Ebf2)

Protein Structure

UniProt Annotation

Function

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. {ECO:0000269PubMed:16326388}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

In adult expressed in olfactory epithelium and at a much lower level in Purkinje cells of the cerebellum. In embryo expressed in epithalamus, in cells near the ventricular zone of mesencephalon and on the ventral surface of rhombencephalon, in the developing vomeronasal organ, at a lower level in developing spinal cord. Not expressed in developing retina, inner ear, dorsal root ganglia, trigeminal ganglia and glossopharyngeal ganglia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001709	cell fate determination
GO:0006351	transcription, DNA-templated
GO:0035563	positive regulation of chromatin binding
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050873	brown fat cell differentiation
GO:0060612	adipose tissue development