InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eya3

Summary

InnateDB Protein

IDBP-718675.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eya3

Protein Name

Synonyms

AI844637;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000136812

InnateDB Gene

IDBG-194149 (Eya3)

Protein Structure

UniProt Annotation

Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. The phosphatase activity has been shown in vitro. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. May play a role in mediating the induction and differentiation of cranial placodes. {ECO:0000250, ECO:0000269PubMed:10490620}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in branchial arches, CNS and developing eye.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007275	multicellular organismal development
GO:0010212	response to ionizing radiation
GO:0016576	histone dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045739	positive regulation of DNA repair

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109339

InterPro

IPR006545 EYA domain
IPR023214 HAD-like domain

PFAM

PF00702
PF08282
PF13419

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P97480

PhosphoSite

PhosphoSite-P97480

TrEMBL

UniProt Splice Variant

Entrez Gene

14050

UniGene

Mm.408529

RefSeq

MGI ID

MGI Symbol

Eya3

OMIM

CCDS

CCDS18731

HPRD

IMGT

EMBL

AJ007996 AL627130 CH466552 U61112 U81604

GenPept

AAB42068 AAB48019 CAA07819 EDL30095