InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eya3

Summary

InnateDB Gene

IDBG-194149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eya3

Gene Name

eyes absent 3 homolog (Drosophila)

Synonyms

AI844637

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028886

Encoded Proteins

IDBP-194151

eyes absent 3 homolog (Drosophila)

IDBP-194153

eyes absent 3 homolog (Drosophila)

IDBP-194155

eyes absent 3 homolog (Drosophila)

IDBP-538024

eyes absent 3 homolog (Drosophila)

IDBP-718675

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158161:
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. A similar protein in mice acts as a transcriptional activator. [provided by RefSeq, Jul 2008]
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3\' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:132638987-132724765

Strand

Forward strand

Band

D2.3

Transcripts

ENSMUST00000081726	ENSMUSP00000080425
ENSMUST00000020197	ENSMUSP00000020197
ENSMUST00000079157	ENSMUSP00000078157
ENSMUST00000135299	ENSMUSP00000123045
ENSMUST00000127682
ENSMUST00000134868
ENSMUST00000157029
ENSMUST00000145668
ENSMUST00000142998
ENSMUST00000142301
ENSMUST00000153809
ENSMUST00000130833
ENSMUST00000180250	ENSMUSP00000136812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006470	protein dephosphorylation
GO:0007275	multicellular organismal development
GO:0010212	response to ionizing radiation
GO:0016576	histone dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045739	positive regulation of DNA repair

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158161

View Gene Order

ENSBTAG00000043989

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.227733 Mm.408529

RefSeq

NM_010166 NM_210071 NM_211357 XM_006538539 XM_006538540

OMIM

CCDS

CCDS18729 CCDS18730 CCDS18731

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas