InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HTR3B

Summary

InnateDB Protein

IDBP-71883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HTR3B

Protein Name

5-hydroxytryptamine (serotonin) receptor 3B

Synonyms

5-HT3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000260191

InnateDB Gene

IDBG-71881 (HTR3B)

Protein Structure

UniProt Annotation

Function

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. {ECO:0000269PubMed:12867984}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21138434}; Multi-pass membrane protein {ECO:0000269PubMed:21138434}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Disease Associations

Tissue Specificity

Expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus and the amygdala. Detected in the kidney and testis as well as in monocytes of the spleen, small and large intestine, uterus, prostate, ovary and placenta. {ECO:0000269PubMed:10521471, ECO:0000269PubMed:9950429}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004993	serotonin receptor activity
GO:0005216	ion channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005232	serotonin-activated cation-selective channel activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007210	serotonin receptor signaling pathway
GO:0007268	synaptic transmission
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
IPR008132 5-hydroxytryptamine 3 receptor
IPR008133 5-hydroxytryptamine 3 receptor, A subunit
IPR008134 5-hydroxytryptamine 3 receptor, B subunit

PFAM

PF02932
PF02931

PRINTS

PR00252
PR01708
PR01709
PR01710

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95264