InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALOX5

Summary

InnateDB Protein

IDBP-71895.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5

Protein Name

arachidonate 5-lipoxygenase

Synonyms

5-LO; 5-LOX; 5LPG; LOG5;

Species

Homo sapiens

Ensembl Protein

ENSP00000363512

InnateDB Gene

IDBG-71893 (ALOX5)

Protein Structure

UniProt Annotation

Function

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. {ECO:0000269PubMed:21233389}.

Subcellular Localization

Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	25 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0031965	nuclear membrane