InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ALOX5

Summary

InnateDB Gene

IDBG-71893.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALOX5

Gene Name

arachidonate 5-lipoxygenase

Synonyms

5-LO; 5-LOX; 5LPG; LOG5

Species

Homo sapiens

Ensembl Gene

ENSG00000012779

Encoded Proteins

IDBP-71895

arachidonate 5-lipoxygenase

IDBP-601868

arachidonate 5-lipoxygenase

IDBP-811641

arachidonate 5-lipoxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:45374176-45446119

Strand

Forward strand

Band

q11.21

Transcripts

ENST00000374391	ENSP00000363512
ENST00000483623
ENST00000475300
ENST00000493336
ENST00000481117
ENST00000498461
ENST00000542434	ENSP00000437634
ENST00000612635	ENSP00000483803

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	25 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004051	arachidonate 5-lipoxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872	metal ion binding

Biological Process

GO:0002540	leukotriene production involved in inflammatory response
GO:0006691	leukotriene metabolic process
GO:0006954	inflammatory response
GO:0019369	arachidonic acid metabolic process
GO:0019370	leukotriene biosynthetic process
GO:0019372	lipoxygenase pathway
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:2001300	lipoxin metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016363	nuclear matrix
GO:0031965	nuclear membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025701

View Gene Order

ENSBTAG00000020319

Not yet available

Pathways

NETPATH

NetPath_17

IL5 pathway

REACTOME

REACT_150209

Synthesis of 5-eicosatetraenoic acids pathway

REACT_150420

Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway

REACT_150320

Synthesis of Lipoxins (LX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa00590

Arachidonic acid metabolism pathway

hsa05145

Toxoplasmosis pathway

INOH

INOH website

Prostaglandin Leukotriene metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000698 NM_001256153 NM_001256154

HUGO

OMIM

CCDS

CCDS58078 CCDS7212

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas