InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lin28a

Summary

InnateDB Protein

IDBP-718955.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lin28a

Protein Name

Synonyms

AL024421; ENSMUSG00000070700; Gm10299; Lin-28; lin-28A; Lin28; Tex17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135608

InnateDB Gene

IDBG-195575 (Lin28a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0008270	zinc ion binding
GO:0031369	translation initiation factor binding
GO:0035198	miRNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007281	germ cell development
GO:0010586	miRNA metabolic process
GO:0010587	miRNA catabolic process
GO:0019827	stem cell maintenance
GO:0031054	pre-miRNA processing
GO:0031123	RNA 3'-end processing
GO:0045666	positive regulation of neuron differentiation
GO:0045686	negative regulation of glial cell differentiation
GO:0045727	positive regulation of translation
GO:0060964	regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule

Protein Structure and Domains

PDB ID

MGI:1890546

InterPro

IPR001878 Zinc finger, CCHC-type
IPR002059 Cold-shock protein, DNA-binding
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF00098
PF00313

PRINTS

PR00050

PIRSF

SMART

SM00343

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

H3BL11

UniProt Splice Variant

Entrez Gene

83557

UniGene

Mm.421761

RefSeq

MGI ID

MGI Symbol

Lin28a

OMIM

CCDS

HPRD

IMGT

EMBL

AL670680

GenPept