InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAIAP2

Summary

InnateDB Protein

IDBP-71914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAIAP2

Protein Name

BAI1-associated protein 2

Synonyms

BAP2; FLAF3; IRSP53;

Species

Homo sapiens

Ensembl Protein

ENSP00000316338

InnateDB Gene

IDBG-71912 (BAIAP2)

Protein Structure

UniProt Annotation

Function

Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269PubMed:11130076, ECO:0000269PubMed:11696321, ECO:0000269PubMed:14752106, ECO:0000269PubMed:17115031, ECO:0000269PubMed:19366662}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta. {ECO:0000269PubMed:10332026, ECO:0000269PubMed:10343108, ECO:0000269PubMed:11157984}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0008286	insulin receptor signaling pathway
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0016358	dendrite development
GO:0032956	regulation of actin cytoskeleton organization
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087	innate immune response
GO:0046847	filopodium assembly
GO:0048167	regulation of synaptic plasticity
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030175	filopodium
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome