InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBTB16

Summary

InnateDB Protein

IDBP-72006.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBTB16

Protein Name

zinc finger and BTB domain containing 16

Synonyms

PLZF; ZNF145;

Species

Homo sapiens

Ensembl Protein

ENSP00000338157

InnateDB Gene

IDBG-72004 (ZBTB16)

Protein Structure

UniProt Annotation

Function

Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000269PubMed:14528312}.

Subcellular Localization

Nucleus.

Disease Associations

Skeletal defects, genital hypoplasia, and mental retardation (SGYMR) [MIM:612447]: A disorder characterized by mental retardation, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia. {ECO:0000269PubMed:18611983}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=A chromosomal aberration involving ZBTB16 may be a cause of acute promyelocytic leukemia (APL). Translocation t(11;17)(q32;q21) with RARA.

Tissue Specificity

Within the hematopoietic system, PLZF is expressed in bone marrow, early myeloid cell lines and peripheral blood mononuclear cells. Also expressed in the ovary, and at lower levels, in the kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	161 [view]
Protein-Protein	156 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001501	skeletal system development
GO:0001823	mesonephros development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009952	anterior/posterior pattern specification
GO:0016567	protein ubiquitination
GO:0030097	hemopoiesis
GO:0030099	myeloid cell differentiation
GO:0032332	positive regulation of chondrocyte differentiation
GO:0034504	protein localization to nucleus
GO:0035116	embryonic hindlimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0042733	embryonic digit morphogenesis
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045600	positive regulation of fat cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045778	positive regulation of ossification
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048133	male germ-line stem cell division
GO:0051138	positive regulation of NK T cell differentiation
GO:0051216	cartilage development
GO:0061036	positive regulation of cartilage development

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0017053	transcriptional repressor complex