InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARK7

Summary

InnateDB Protein

IDBP-722570.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARK7

Protein Name

Synonyms

DJ-1; DJ1; HEL-S-67p;

Species

Homo sapiens

Ensembl Protein

ENSP00000465404

InnateDB Gene

IDBG-88298 (PARK7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	89 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008233	peptidase activity
GO:0016532	superoxide dismutase copper chaperone activity
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor
GO:0019899	enzyme binding
GO:0019955	cytokine binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044388	small protein activating enzyme binding
GO:0044390	small protein conjugating enzyme binding
GO:0050681	androgen receptor binding
GO:0097110	scaffold protein binding
GO:1903135	cupric ion binding
GO:1903136	cuprous ion binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0006508	proteolysis
GO:0006914	autophagy
GO:0006954	inflammatory response
GO:0007005	mitochondrion organization
GO:0007338	single fertilization
GO:0010629	negative regulation of gene expression
GO:0032091	negative regulation of protein binding
GO:0032757	positive regulation of interleukin-8 production
GO:0034599	cellular response to oxidative stress
GO:0042743	hydrogen peroxide metabolic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046826	negative regulation of protein export from nucleus
GO:0050727	regulation of inflammatory response
GO:0050821	protein stabilization
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0060548	negative regulation of cell death
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070301	cellular response to hydrogen peroxide
GO:0090073	positive regulation of protein homodimerization activity
GO:1900182	positive regulation of protein localization to nucleus
GO:1901215	negative regulation of neuron death
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1901671	positive regulation of superoxide dismutase activity
GO:1901984	negative regulation of protein acetylation
GO:1903073	negative regulation of death-inducing signaling complex assembly
GO:1903094	negative regulation of protein K48-linked deubiquitination
GO:1903122	negative regulation of TRAIL-activated apoptotic signaling pathway
GO:2000157	negative regulation of ubiquitin-specific protease activity
GO:2000825	positive regulation of androgen receptor activity
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016605	PML body
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome