Version 5.4
Homo sapiens Gene: PARK7
Summary
InnateDB Gene IDBG-88298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARK7
Gene Name parkinson protein 7
Synonyms DJ-1; DJ1; HEL-S-67p
Species Homo sapiens
Ensembl Gene ENSG00000116288
Encoded Proteins
IDBP-88300
parkinson protein 7
IDBP-722594
IDBP-88304
parkinson protein 7
IDBP-88306
parkinson protein 7
IDBP-722570
IDBP-479015
parkinson protein 7
IDBP-721598
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:7954291-7985505
Strand Forward strand
Band p36.23
Transcripts
ENST00000338639 ENSP00000340278
ENST00000377493 ENSP00000466242
ENST00000377491 ENSP00000366711
ENST00000377488 ENSP00000366708
ENST00000493373 ENSP00000465404
ENST00000460192
ENST00000493678 ENSP00000418770
ENST00000465354
ENST00000497113
ENST00000469225 ENSP00000466756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 90 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0004601 peroxidase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008233 peptidase activity
GO:0016532 superoxide dismutase copper chaperone activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0019899 enzyme binding
GO:0019955 cytokine binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044388 small protein activating enzyme binding
GO:0044390 small protein conjugating enzyme binding
GO:0050681 androgen receptor binding
GO:0051920 peroxiredoxin activity
GO:0097110 scaffold protein binding
GO:1903135 cupric ion binding
GO:1903136 cuprous ion binding
GO:1990381 ubiquitin-specific protease binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0006469 negative regulation of protein kinase activity
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0006954 inflammatory response
GO:0007005 mitochondrion organization
GO:0007338 single fertilization
GO:0008344 adult locomotory behavior
GO:0010629 negative regulation of gene expression
GO:0032091 negative regulation of protein binding
GO:0032757 positive regulation of interleukin-8 production
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0042542 response to hydrogen peroxide
GO:0042743 hydrogen peroxide metabolic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046826 negative regulation of protein export from nucleus
GO:0050727 regulation of inflammatory response
GO:0050821 protein stabilization
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051881 regulation of mitochondrial membrane potential
GO:0051899 membrane depolarization
GO:0055114 oxidation-reduction process
GO:0060081 membrane hyperpolarization
GO:0060548 negative regulation of cell death
GO:0060765 regulation of androgen receptor signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0090073 positive regulation of protein homodimerization activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901215 negative regulation of neuron death
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1901671 positive regulation of superoxide dismutase activity
GO:1901984 negative regulation of protein acetylation
GO:1903073 negative regulation of death-inducing signaling complex assembly
GO:1903094 negative regulation of protein K48-linked deubiquitination
GO:1903122 negative regulation of TRAIL-activated apoptotic signaling pathway
GO:2000157 negative regulation of ubiquitin-specific protease activity
GO:2000277 positive regulation of oxidative phosphorylation uncoupler activity
GO:2000825 positive regulation of androgen receptor activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016605 PML body
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028964
View Gene Order
ENSBTAG00000020518
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
Cross-References
SwissProt Q99497
TrEMBL V9HWC2
UniProt Splice Variant
Entrez Gene 11315
UniGene
RefSeq NM_001123377 NM_007262 XM_005263424
HUGO HGNC:16369
OMIM 602533
CCDS CCDS93
HPRD 03961
IMGT
EMBL AB045294 AB073864 AF021819 AK312000 AL034417 AY648999 BC008188 CH471130 D61380 EU794641
GenPept AAC12806 AAH08188 AAT68961 ACJ13695 BAA09603 BAB71782 BAG34938 CAB52550 EAW71591
RNA Seq Atlas 102724203 11315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca