InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOA5

Summary

InnateDB Protein

IDBP-72436.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOA5

Protein Name

apolipoprotein A-V

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000227665

InnateDB Gene

IDBG-72432 (APOA5)

Protein Structure

UniProt Annotation

Function

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO:0000250, ECO:0000269PubMed:11588264, ECO:0000269PubMed:12899628, ECO:0000269PubMed:15528295}.

Subcellular Localization

Secreted {ECO:0000269PubMed:12810715}.

Disease Associations

Hypertriglyceridemia, familial (FHTR) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Hyperlipoproteinemia 5 (HLPP5) [MIM:144650]: Characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin- dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A). {ECO:0000269PubMed:16200213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver and plasma. {ECO:0000269PubMed:11577099, ECO:0000269PubMed:11588264, ECO:0000269PubMed:15528295}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008047	enzyme activator activity
GO:0008201	heparin binding
GO:0008289	lipid binding
GO:0019899	enzyme binding
GO:0031210	phosphatidylcholine binding
GO:0035473	lipase binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0060229	lipase activator activity
GO:0060230	lipoprotein lipase activator activity
GO:0070325	lipoprotein particle receptor binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0010898	positive regulation of triglyceride catabolic process
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling
GO:0019433	triglyceride catabolic process
GO:0042157	lipoprotein metabolic process
GO:0042246	tissue regeneration
GO:0042632	cholesterol homeostasis
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045723	positive regulation of fatty acid biosynthetic process
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050996	positive regulation of lipid catabolic process
GO:0051006	positive regulation of lipoprotein lipase activity
GO:0055090	acylglycerol homeostasis
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0034361	very-low-density lipoprotein particle
GO:0034364	high-density lipoprotein particle
GO:0042627	chylomicron