InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RRAGB

Summary

InnateDB Protein

IDBP-72469.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RRAGB

Protein Name

Ras-related GTP binding B

Synonyms

bA465E19.1; RAGB;

Species

Homo sapiens

Ensembl Protein

ENSP00000262850

InnateDB Gene

IDBG-72465 (RRAGB)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. {ECO:0000269PubMed:18497260, ECO:0000269PubMed:20381137, ECO:0000269PubMed:9394008}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:7499430}. Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0032561	guanyl ribonucleotide binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670

PRINTS

PR00449
PR00328

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VZM2