Version 5.4
Homo sapiens Gene: RRAGB
Summary
InnateDB Gene IDBG-72465.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RRAGB
Gene Name Ras-related GTP binding B
Synonyms bA465E19.1; RAGB
Species Homo sapiens
Ensembl Gene ENSG00000083750
Encoded Proteins
IDBP-72467
Ras-related GTP binding B
IDBP-72469
Ras-related GTP binding B
IDBP-374090
Ras-related GTP binding B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:55717739-55758774
Strand Forward strand
Band p11.21
Transcripts
ENST00000374941 ENSP00000364077
ENST00000262850 ENSP00000262850
ENST00000414239 ENSP00000410630
ENST00000498762
ENST00000474757
ENST00000475061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0032561 guanyl ribonucleotide binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032008 positive regulation of TOR signaling
GO:0034613 cellular protein localization
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041658
View Gene Order
ENSBTAG00000012980
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04150
mTOR signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.50282
RefSeq NM_006064 NM_016656
HUGO
OMIM
CCDS CCDS14371 CCDS14372
HPRD 06710
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca