InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hnf1a

Summary

InnateDB Protein

IDBP-724910.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnf1a

Protein Name

Synonyms

AI323641; Hnf-1; HNF1; HNF1-alpha; HNF1[a]; Hnf1alpha; LFB1; Tcf-1; Tcf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135678

InnateDB Gene

IDBG-193173 (Hnf1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 230 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	230 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001824	blastocyst development
GO:0001889	liver development
GO:0001890	placenta development
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006633	fatty acid biosynthetic process
GO:0006699	bile acid biosynthetic process
GO:0006783	heme biosynthetic process
GO:0006979	response to oxidative stress
GO:0008104	protein localization
GO:0008203	cholesterol metabolic process
GO:0009749	response to glucose
GO:0015721	bile acid and bile salt transport
GO:0015908	fatty acid transport
GO:0030073	insulin secretion
GO:0030111	regulation of Wnt signaling pathway
GO:0030326	embryonic limb morphogenesis
GO:0031018	endocrine pancreas development
GO:0042593	glucose homeostasis
GO:0043691	reverse cholesterol transport
GO:0045453	bone resorption
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046883	regulation of hormone secretion
GO:0048341	paraxial mesoderm formation
GO:0048608	reproductive structure development
GO:0050796	regulation of insulin secretion
GO:0060395	SMAD protein signal transduction

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0045120	pronucleus

Protein Structure and Domains

PDB ID

MGI:98504

InterPro

IPR006899 Hepatocyte nuclear factor 1, N-terminal
IPR009057 Homeodomain-like
IPR010982 Lambda repressor-like, DNA-binding domain
IPR023219 Hepatocyte nuclear factor 1, dimerisation domain

PFAM

PF04814
PF13413

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-