Version 5.4
Homo sapiens Protein: ZSCAN4
Summary
InnateDB Protein IDBP-72514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZSCAN4
Protein Name zinc finger and SCAN domain containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000321963
InnateDB Gene IDBG-72512 (ZSCAN4)
Protein Structure
UniProt Annotation
Function Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00187}. Chromosome, telomere {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010833 telomere maintenance via telomere lengthening
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003309 Transcription regulator SCAN
IPR007087 Zinc finger, C2H2
IPR008916 Retrovirus capsid, C-terminal
IPR015880 Zinc finger, C2H2-like
PFAM PF02023
PF00096
PRINTS
PIRSF
SMART SM00431
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NAM6
PhosphoSite PhosphoSite-Q8NAM6
TrEMBL
UniProt Splice Variant
Entrez Gene 201516
UniGene Hs.469663
RefSeq NP_689890
HUGO HGNC:23709
OMIM 613419
CCDS CCDS12958
HPRD 15899
IMGT
EMBL AK092424 BC101738 BC101740
GenPept AAI01739 AAI01741 BAC03886

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca