InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp2a2

Summary

InnateDB Protein

IDBP-725144.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp2a2

Protein Name

Synonyms

9530097L16Rik; D5Wsu150e; mKIAA4195; SERCA2; SERCA2B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000135935

InnateDB Gene

IDBG-198239 (Atp2a2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005388	calcium-transporting ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006937	regulation of muscle contraction
GO:0006984	ER-nucleus signaling pathway
GO:0008152	metabolic process
GO:0045822	negative regulation of heart contraction
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:88110

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR005782 Calcium-transporting P-type ATPase, subfamily IIA, SERCA-type
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

J3KMM5

UniProt Splice Variant

Entrez Gene

11938

UniGene

Mm.412722

RefSeq

MGI ID

MGI Symbol

Atp2a2

OMIM

CCDS

HPRD

IMGT

EMBL

AC113285

GenPept