InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOC3

Summary

InnateDB Protein

IDBP-72566.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC3

Protein Name

apolipoprotein C-III

Synonyms

APOCIII; HALP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000227667

InnateDB Gene

IDBG-72562 (APOC3)

Protein Structure

UniProt Annotation

Function

Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.

Subcellular Localization

Secreted.

Disease Associations

Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269PubMed:2022742}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0030234	enzyme regulator activity
GO:0055102	lipase inhibitor activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006642	triglyceride mobilization
GO:0006869	lipid transport
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0010897	negative regulation of triglyceride catabolic process
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0010987	negative regulation of high-density lipoprotein particle clearance
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0019433	triglyceride catabolic process
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034382	chylomicron remnant clearance
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0043434	response to peptide hormone
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0070328	triglyceride homeostasis
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0034361	very-low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome