InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOC3

Summary

InnateDB Gene

IDBG-72562.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC3

Gene Name

apolipoprotein C-III

Synonyms

APOCIII; HALP2

Species

Homo sapiens

Ensembl Gene

ENSG00000110245

Encoded Proteins

IDBP-72566

apolipoprotein C-III

IDBP-72568

apolipoprotein C-III

IDBP-383346

apolipoprotein C-III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:116829706-116833072

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000227667	ENSP00000227667
ENST00000375345	ENSP00000364494
ENST00000433777	ENSP00000410614
ENST00000470144

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0030234	enzyme regulator activity
GO:0055102	lipase inhibitor activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006642	triglyceride mobilization
GO:0006869	lipid transport
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007584	response to nutrient
GO:0007603	phototransduction, visible light
GO:0008203	cholesterol metabolic process
GO:0010897	negative regulation of triglyceride catabolic process
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0010987	negative regulation of high-density lipoprotein particle clearance
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0019433	triglyceride catabolic process
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034382	chylomicron remnant clearance
GO:0042157	lipoprotein metabolic process
GO:0042493	response to drug
GO:0042632	cholesterol homeostasis
GO:0042953	lipoprotein transport
GO:0043434	response to peptide hormone
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0070328	triglyceride homeostasis
GO:0071333	cellular response to glucose stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0034361	very-low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome