InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOC3

Summary

InnateDB Protein

IDBP-72568.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOC3

Protein Name

apolipoprotein C-III

Synonyms

APOCIII; HALP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000364494

InnateDB Gene

IDBG-72562 (APOC3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005543	phospholipid binding
GO:0008289	lipid binding
GO:0015485	cholesterol binding
GO:0030234	enzyme regulator activity
GO:0055102	lipase inhibitor activity
GO:0070653	high-density lipoprotein particle receptor binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006641	triglyceride metabolic process
GO:0006869	lipid transport
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007603	phototransduction, visible light
GO:0010897	negative regulation of triglyceride catabolic process
GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance
GO:0010987	negative regulation of high-density lipoprotein particle clearance
GO:0010989	negative regulation of low-density lipoprotein particle clearance
GO:0019433	triglyceride catabolic process
GO:0032489	regulation of Cdc42 protein signal transduction
GO:0033344	cholesterol efflux
GO:0033700	phospholipid efflux
GO:0034375	high-density lipoprotein particle remodeling
GO:0034379	very-low-density lipoprotein particle assembly
GO:0034382	chylomicron remnant clearance
GO:0042157	lipoprotein metabolic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0044281	small molecule metabolic process
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0045833	negative regulation of lipid metabolic process
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050995	negative regulation of lipid catabolic process
GO:0051005	negative regulation of lipoprotein lipase activity
GO:0060621	negative regulation of cholesterol import
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0034361	very-low-density lipoprotein particle
GO:0034363	intermediate-density lipoprotein particle
GO:0034366	spherical high-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome