InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF11A

Summary

InnateDB Protein

IDBP-725719.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF11A

Protein Name

Synonyms

CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER;

Species

Homo sapiens

Ensembl Protein

ENSP00000465500

InnateDB Gene

IDBG-4279 (TNFRSF11A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0019955	cytokine binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0002250	adaptive immune response
GO:0002548	monocyte chemotaxis
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0009314	response to radiation
GO:0030316	osteoclast differentiation
GO:0032496	response to lipopolysaccharide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0034097	response to cytokine
GO:0034612	response to tumor necrosis factor
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507	positive regulation of JUN kinase activity
GO:0048535	lymph node development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060086	circadian temperature homeostasis
GO:0060749	mammary gland alveolus development
GO:0070555	response to interleukin-1
GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847	TNFSF11-mediated signaling pathway
GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling