Version 5.4
Homo sapiens Gene: TNFRSF11A
Summary
InnateDB Gene IDBG-4279.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF11A
Gene Name tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
Species Homo sapiens
Ensembl Gene ENSG00000141655
Encoded Proteins
IDBP-4283
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
IDBP-725719
IDBP-813491
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
IDBP-813493
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:62325287-62391292
Strand Forward strand
Band q21.33
Transcripts
ENST00000269485 ENSP00000269485
ENST00000587697
ENST00000586569 ENSP00000465500
ENST00000592013
ENST00000616710 ENSP00000479567
ENST00000617039 ENSP00000482466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0019955 cytokine binding
GO:0046872 metal ion binding
Biological Process
GO:0001503 ossification
GO:0002250 adaptive immune response
GO:0002548 monocyte chemotaxis
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0008284 positive regulation of cell proliferation
GO:0009314 response to radiation
GO:0030316 osteoclast differentiation
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0034612 response to tumor necrosis factor
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043507 positive regulation of JUN kinase activity
GO:0048535 lymph node development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060086 circadian temperature homeostasis
GO:0060749 mammary gland alveolus development
GO:0070555 response to interleukin-1
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 TNFSF11-mediated signaling pathway
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
Cellular Component
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026321
View Gene Order
ENSBTAG00000007569
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.204044 Hs.598412 Hs.621477
RefSeq NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839 XM_005266777
HUGO
OMIM
CCDS CCDS11980 CCDS59324 CCDS74227 CCDS74228
HPRD 04609
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca