InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCYAP1

Summary

InnateDB Protein

IDBP-725900.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1

Protein Name

Synonyms

PACAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000462647

InnateDB Gene

IDBG-368 (ADCYAP1)

Protein Structure

UniProt Annotation

Function

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. {ECO:0000269PubMed:11175907, ECO:0000269PubMed:23800469}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0016521	pituitary adenylate cyclase activating polypeptide activity
GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001662	behavioral fear response
GO:0001821	histamine secretion
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus
GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0010656	negative regulation of muscle cell apoptotic process
GO:0010976	positive regulation of neuron projection development
GO:0019233	sensory perception of pain
GO:0019933	cAMP-mediated signaling
GO:0021983	pituitary gland development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031175	neuron projection development
GO:0032755	positive regulation of interleukin-6 production
GO:0032854	positive regulation of Rap GTPase activity
GO:0032880	regulation of protein localization
GO:0034259	negative regulation of Rho GTPase activity
GO:0042594	response to starvation
GO:0043267	negative regulation of potassium ion transport
GO:0045471	response to ethanol
GO:0045786	negative regulation of cell cycle
GO:0045860	positive regulation of protein kinase activity
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046034	ATP metabolic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0060078	regulation of postsynaptic membrane potential
GO:0060124	positive regulation of growth hormone secretion
GO:0060253	negative regulation of glial cell proliferation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070445	regulation of oligodendrocyte progenitor proliferation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0090274	positive regulation of somatostatin secretion