Version 5.4
Homo sapiens Protein: MBD2
Summary
InnateDB Protein IDBP-725979.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MBD2
Protein Name
Synonyms DMTase; NY-CO-41;
Species Homo sapiens
Ensembl Protein ENSP00000464554
InnateDB Gene IDBG-3532 (MBD2)
Protein Structure
UniProt Annotation
Function Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269PubMed:10471499, ECO:0000269PubMed:10947852, ECO:0000269PubMed:12665568, ECO:0000269PubMed:16415179, ECO:0000269PubMed:24307175, ECO:0000269PubMed:9774669}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12183469, ECO:0000269PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.
Disease Associations
Tissue Specificity Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269PubMed:10050851}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 47 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003696 satellite DNA binding
GO:0005515 protein binding
GO:0008327 methyl-CpG binding
GO:0019904 protein domain specific binding
GO:0031492 nucleosomal DNA binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0043044 ATP-dependent chromatin remodeling
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001739 Methyl-CpG DNA binding
IPR016177 DNA-binding domain
PFAM PF01429
PRINTS
PIRSF
SMART SM00391
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBB5
PhosphoSite PhosphoSite-Q9UBB5
TrEMBL A0A024R2B8
UniProt Splice Variant
Entrez Gene 8932
UniGene Hs.713852
RefSeq NP_056647
HUGO HGNC:6917
OMIM 603547
CCDS CCDS45871
HPRD 04647
IMGT
EMBL AF072242 AF072246 AF120988 AF120989 AF120990 AF120991 AF120992 AF120993 BC032638 CH471096
GenPept AAC68871 AAC68875 AAD56596 AAD56597 AAH32638 EAW62998 EAW62999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca