Version 5.4
Homo sapiens Protein: AQP4
Summary
InnateDB Protein IDBP-726436.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP4
Protein Name
Synonyms HMIWC2; MIWC;
Species Homo sapiens
Ensembl Protein ENSP00000462597
InnateDB Gene IDBG-1836 (AQP4)
Protein Structure
UniProt Annotation
Function Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Brain - muscle >> heart, kidney, lung, and trachea.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005372 water transmembrane transporter activity
GO:0015250 water channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0007399 nervous system development
GO:0007588 excretion
GO:0050891 multicellular organismal water homeostasis
GO:0055085 transmembrane transport
GO:0071346 cellular response to interferon-gamma
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
PFAM PF00230
PRINTS PR00783
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P55087
PhosphoSite PhosphoSite-P55087
TrEMBL
UniProt Splice Variant
Entrez Gene 361
UniGene Hs.593410
RefSeq NP_004019
HUGO HGNC:637
OMIM 600308
CCDS CCDS58617
HPRD 02631
IMGT
EMBL AC018371 BC022286 D63412 U34845 U34846 U63622 U63623
GenPept AAB26957 AAB26958 AAC50284 AAC52112 AAH22286 BAA09715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca