InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AQP4

Summary

InnateDB Gene

IDBG-1836.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AQP4

Gene Name

aquaporin 4

Synonyms

HMIWC2; MIWC

Species

Homo sapiens

Ensembl Gene

ENSG00000171885

Encoded Proteins

IDBP-1840

aquaporin 4

IDBP-1842

aquaporin 4

IDBP-366172

aquaporin 4

IDBP-726436

IDBP-726034

IDBP-811831

aquaporin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:26852038-26865818

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000383170	ENSP00000372656
ENST00000383168	ENSP00000372654
ENST00000440832	ENSP00000393121
ENST00000581374	ENSP00000462597
ENST00000578776	ENSP00000462075
ENST00000583022
ENST00000584088
ENST00000622234	ENSP00000484446

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005372	water transmembrane transporter activity
GO:0015250	water channel activity
GO:0015288	porin activity

Biological Process

GO:0006810	transport
GO:0006833	water transport
GO:0007399	nervous system development
GO:0007565	female pregnancy
GO:0007588	excretion
GO:0007605	sensory perception of sound
GO:0009314	response to radiation
GO:0015670	carbon dioxide transport
GO:0030104	water homeostasis
GO:0042538	hyperosmotic salinity response
GO:0050891	multicellular organismal water homeostasis
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0055085	transmembrane transport
GO:0070295	renal water absorption
GO:0071346	cellular response to interferon-gamma
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024411

View Gene Order

ENSBTAG00000019037

Not yet available

Pathways

NETPATH

REACTOME

REACT_23826

Passive transport by Aquaporins pathway

REACT_24023

Vasopressin regulates renal water homeostasis via Aquaporins pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_23887

Aquaporin-mediated transport pathway

KEGG

hsa04962

Vasopressin-regulated water reabsorption pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.315369 Hs.593410

RefSeq

NM_001650 NM_004028

HUGO

OMIM

CCDS

CCDS11889 CCDS58617

HPRD

02631

IMGT

EMBL

GenPept

RNA Seq Atlas