InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGDIA

Summary

InnateDB Protein

IDBP-72686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGDIA

Protein Name

Rho GDP dissociation inhibitor (GDI) alpha

Synonyms

GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000269321

InnateDB Gene

IDBG-72684 (ARHGDIA)

Protein Structure

UniProt Annotation

Function

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269PubMed:20400958, ECO:0000269PubMed:23434736}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:23434736}.

Disease Associations

Nephrotic syndrome 8 (NPHS8) [MIM:615244]: A form of nephrotic syndrome, a renal disease clinically characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show diffuse mesangial sclerosis, with small glomeruli, hypercellularity, increased extracellular matrix, and contracted/collapsed glomerular tufts surrounded by immature or abnormal podocytes. {ECO:0000269PubMed:23434736}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 101 experimentally validated interaction(s) in this database.

Experimentally validated
Total	101 [view]
Protein-Protein	99 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005094	Rho GDP-dissociation inhibitor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006928	cellular component movement
GO:0007162	negative regulation of cell adhesion
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0030336	negative regulation of cell migration
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0071526	semaphorin-plexin signaling pathway