InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR4A2

Summary

InnateDB Protein

IDBP-72698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A2

Protein Name

nuclear receptor subfamily 4, group A, member 2

Synonyms

HZF-3; NOT; NURR1; RNR1; TINUR;

Species

Homo sapiens

Ensembl Protein

ENSP00000344479

InnateDB Gene

IDBG-72696 (NR4A2)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mostly nuclear; oxidative stress promotes cytoplasmic localization.

Disease Associations

Tissue Specificity

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	15 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001666	response to hypoxia
GO:0001764	neuron migration
GO:0001975	response to amphetamine
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0008344	adult locomotory behavior
GO:0009791	post-embryonic development
GO:0010035	response to inorganic substance
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0016265	death
GO:0017085	response to insecticide
GO:0021952	central nervous system projection neuron axonogenesis
GO:0021953	central nervous system neuron differentiation
GO:0021986	habenula development
GO:0030182	neuron differentiation
GO:0030522	intracellular receptor signaling pathway
GO:0031668	cellular response to extracellular stimulus
GO:0034599	cellular response to oxidative stress
GO:0042053	regulation of dopamine metabolic process
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042551	neuron maturation
GO:0043085	positive regulation of catalytic activity
GO:0043401	steroid hormone mediated signaling pathway
GO:0043524	negative regulation of neuron apoptotic process
GO:0043576	regulation of respiratory gaseous exchange
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051866	general adaptation syndrome
GO:0071542	dopaminergic neuron differentiation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003073 Orphan nuclear receptor, NURR type
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01284
PR01287
PR01292

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt